[20] Perou CM, Sorlie T, Eisen MB, et al. Molecular portraits of human
breast tumours. Nature 2000;406:747–52.
http://dx.doi.org/10. 1038/35021093 .[21] Glinsky GV, Glinskii AB, Stephenson AJ, Hoffman RM, Gerald WL.
Gene expression profiling predicts clinical outcome of prostate
cancer. J Clin Invest 2004;113:913–23.
http://dx.doi.org/10.1172/ JCI200420032.
[22] Taylor BS, Schultz N, Hieronymus H, et al. Integrative genomic
profiling of human prostate cancer. Cancer Cell 2010;18:11–22.
http://dx.doi.org/10.1016/j.ccr.2010.05.026 .[23] Tibshirani R, Walther G, Hastie T. Estimating the number of clusters
in a data set via the gap statistic. J R Stat Soc Ser B (Stat Methodol)
2001;63:411–23.
http://dx.doi.org/10.1111/1467-9868.00293 .[24] Grambsch PM, Therneau TM. Proportional hazards tests and diag-
nostics based on weighted residuals. Biometrika 1994;81:515–26.
http://dx.doi.org/10.1093/biomet/81.3.515.
[25] Kypta RM, Waxman J. Wnt/beta-catenin signalling in prostate
cancer. Nat Rev Urol 2012;9:418–28.
http://dx.doi.org/10.1038/ nrurol.2012.116 .[26] Chen J, Bardes EE, Aronow BJ, Jegga AG. ToppGene Suite for gene list
enrichment analysis and candidate gene prioritization. Nucl Acids
Res 2009;37(Web Server issue):W305–11.
http://dx.doi.org/10. 1093/nar/gkp427 .[27] Pound CR, Partin AW, Eisenberger MA, Chan DW, Pearson JD, Walsh
PC. Natural history of progression after PSA elevation following
radical prostatectomy. JAMA 1999;281:1591–7.
http://dx.doi.org/ 10.1001/jama.281.17.1591.
[28] Li H, Liu W, Chen W, Zhu J, Deng CX, Rodgers GP. Olfactomedin
4 deficiency promotes prostate neoplastic progression and is asso-
ciated with upregulation of the hedgehog-signaling pathway. Sci
Rep 2015;5:16974.
http://dx.doi.org/10.1038/srep16974.
[29]
Thibault A, Figg WD, Bergan RC, et al. A phase II study of 5-aza- 2’deoxycytidine (decitabine) in hormone independent metastatic (D2) prostate cancer. Tumori 1998;84:87–9, PMID: 9619724.
[30] Aytes A, Mitrofanova A, Lefebvre C, et al. Cross-species regulatory
network analysis identifies a synergistic interaction between
FOXM1 and CENPF that drives prostate cancer malignancy. Cancer
Cell 2014;25:638–51.
http://dx.doi.org/10.1016/j.ccr.2014.03.017 .E U R O P E A N U R O L O G Y 7 2 ( 2 0 1 7 ) 5 0 9 – 5 1 8
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