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Table 2 – Study characteristics of all 23 clinical studies sorted on inclusion in meta-analysis, surgical procedure, and biomaterial
Author
Yr
No. of
patients
Sex
Age
range
No. of
patients with
prior surgery
Surgical
procedure
(defect length
in mm)
Biomaterial
(category)
Availability
biomaterial
Type of
added cells
Quality
Assessment +
meta-analysis
1 Atala A
1999
4
M 4–20 yr
4
Inlay (50–150)
BAM, human (D)
Exp
—
Yes
2 El-Kassaby AW 2003
28
M 2–61 yr
Unknown
Inlay (15–160)
BAM, human (D)
Exp
—
Yes
3 El-Kassaby AW 2008
15
M 21–59 yr
9
Inlay (20–180)
BAM, human (D)
Exp
—
Yes
4 Le Roux PJ
2005
9
M 15–56 yr
5
Inlay (10–50)
SIS, porcine (D)
Com
—
Yes
5 Palminteri E
2006
20
M 20–74 yr
16
Inlay (20–80)
SIS, porcine (D)
Com
—
Yes
6 Donkov II
2006
9
M 26–45 yr
5
Inlay (40–60)
SIS, 4-layer, porcine (D)
Com
—
Yes
7 Fiala R
2007
50
M 45–73 yr
Unknown
Inlay (40–140)
SIS, 4-layer, porcine (D)
Com
—
Yes
8 Orabi H
2013
12
M 1.5–15 yr
3
Inlay (15–35)
SIS, 4-layer, porcine (D)
Com
—
Yes
9 Xu YM
2013
28
M 2–69 yr
28
Inlay (35–70)
SIS, 4-layer, porcine (D)
Com
—
Yes
10 Hauser S
2006
5
M 61–80 yr
5
Inlay (35–100)
SIS, 1- and 4 –layer,
porcine (D)
Com
—
Yes
11 Osman NI
2014
5
M 36–66 yr
4
Inlay (?)
De-epidermised dermis,
human (D)
Exp
Autologous buccal
mucosa-derived
keratinocytes and
fibroblasts
Yes
12 Fossum M 2012
6
M 14–44 mo
Unknown
Inlay (?)
Acellular skin, human (D)
Exp
Autologous urothelial
cells
Yes
13 Raya-Rivera A 2013
5
M 10–14 yr
2
Full (40–60)
Polyglycolic acid and
poly-(lactide-co-glycolide
acid) (S)
Exp
Autologous bladder
SMCs and urothelial cells
Yes
14 Bhargava S
2008
5
?
Unknown
5
Inlay (?)
De-epidermised dermis,
human (D)
Exp
Autologous buccal
mucosa-derived
keratinocytes and
fibroblasts
No
a15 Carpenter CP
2012
1
M 68 yr
1
Inlay (25)
Alloderm (D)
Com
—
No
b16 Kim JY
2005
1
M 48 yr
0
Inlay (40)
Alloderm (D)
Com
—
No
b17 Mantovani F
2003
1
M 72 yr
1
Inlay (?)
SIS, porcine (D)
Com
—
No
b18 Lin J
2005
16
M 18–46 yr
Unknown
Full (?)
Acellular skin, human (D)
Exp
—
No (CN)
c19 Villavicencio H 1989
22
?
28–80 yr
Unknown
Inlay + full (?)
Lyophilized dura, human (D)
Exp
—
No (ES)
c20 Glybochko P
2015
1
M 64 yr
Unknown
Unclear (?)
Acellular artery, human (D)
Exp
Autologous buccal
mucosa-derived
keratinocytes
No (RU)
c21 Yang WZ
2011
8
M 4–23 yr
0
Unclear (?)
Acellular skin human (D)
Exp
—
No
d22 Mantovani F
2002
5
M + F 70–79 yr
Unknown
Unclear (?)
SIS, porcine (D)
Com
—
No (IT)
c23 Li P
2009
8
M 8–36 mo
Unknown
Unclear (25–45)
Gelating sponge (N)
Exp
—
No (CN)
c? = unclear; BAM = bladder acellular matrix; CN = Chinese; Com = commercial availability; D = decellularized; ES = Spanish; Exp = experimental availability; IT = Italian; MSC = mesenchymal stem cells; N = natural;
RU = Russian; S = synthetic; SIS = small intestinal submucosa; SMC = smooth muscle cell.
a
Excluded from meta-analysis because same patients were included in long-term follow-up study by Osman et al., 2014 (#11).
b
Excluded from meta-analysis due to case study.
c
Excluded from meta-analysis due to language restrictions defined in Section
2.5 .d
Excluded from meta-analysis due to unclear surgical procedure.
E U R O P E A N U R O L O G Y 7 2 ( 2 0 1 7 ) 5 9 4 – 6 0 6
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