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Table 1 – Study characteristics of all 80 preclinical studies sorted on inclusion in meta-analysis, surgical procedure, and biomaterial
Author
Yr Animal
model
No. of
animals
Sex
Surgical
procedure
(defect length
in mm)
Biomaterial
(category)
Type of added cells
Quality
assessment +
meta-analysis
1 Feng C
2011 Rabbit 28
M Inlay (15)
Acellular corpus
spongiosum,
porcine (D)
Autologous corporal SMCs
and lingual keratinocytes
Yes
2 Ayyildiz A 2006 Rabbit 10
M Inlay (5)
Alloderm + acellular
pericardium,
bovine (D)
—
Yes
3 Chen F
1999 Rabbit 10
M Inlay (10)
BAM, porcine (D)
—
Yes
4 Chun SY
2015 Rabbit 10
M Inlay (20)
BAM, porcine (D)
Autologous minced urethral
muscle and urothelial tissue
Yes
5 Sayeg K
2013 Rabbit 18
M Inlay (35)
BAM, porcine (D)
Autologous bladder SMCs
Yes
6 Huang JW 2014 Rabbit 30
M Inlay (15)
BAM, rabbit (D)
—
Yes
7 Li C
2008 Rabbit 24
M Inlay (20)
BAM, rabbit (D)
Autologous oral keratinocytes
Yes
8 Li C
2013 Rabbit 27
M Inlay (20)
BAM, rabbit (D)
Autologous oral keratinocytes
and TGF-
b
siRNA transfected
fibroblasts
Yes
9 Li H
2014 Rabbit 36
M Inlay (20)
BAM, rabbit (D)
Epithelial-differentiated rabbit
adipose-derived stem cells
Yes
10 Wang F
2014 Rabbit 12
M Inlay (10)
Denuded amnion,
human (D)
Rabbit urothelial cells
Yes
11 Kajbafzadeh
AM
2014 Rabbit 12
M Inlay (5)
Preputial acellular
matrix, human (D)
—
Yes
12 Kawano PR 2012 Rabbit 24
M Inlay (10)
SIS, 1- and 4 –layer,
porcine (D)
—
Yes
13 Guo H
2015 Rabbit 24
M Inlay (20)
SIS, porcine (D)
Autologous keratinocytes and
TIMP siRNA transfected
fibroblasts
Yes
14 Kropp BP
1998 Rabbit 8
M Inlay (10)
SIS, porcine (D)
—
Yes
15 Rotariu P
2002 Rabbit 7
M Inlay (25)
SIS, porcine (D)
—
Yes
16 Villoldo GM 2013 Rabbit 15
M Inlay (10)
SIS, porcine (D)
—
Yes
17 Shokeir A 2003 Dog 21
M Inlay (30)
UAM, dog (D)
—
Yes
18 Huang JW 2015 Rabbit 30
M Inlay (20)
Cellulose (N)
Rabbit lingual keratinocytes
Yes
19 Xie M
2013 Dog 10
F
Inlay (50)
Silk fibroin (N)
Autologous oral keratinocytes
and fibroblasts
Yes
20 Xie M
2013 Dog 9
F
Inlay (30)
Silk fibroin (N)
Dog urothelial cells
Yes
21 Sun D
2014 Rabbit 21
M Inlay (5)
Subcutaneous implanted
autologous minced
muscle (N)
Human umbilical cord MSCs
Yes
22 Xu Y
2014 Rabbit 21
M + F Inlay (5)
Subcutaneous implanted
autologous muscle
microsomes (N)
Human umbilical cord MSCs
Yes
23 Zhang K
2015 Rabbit 12
M Inlay (20)
P(LA/CL) + type I collagen
in combination with ICG-001
(Wnt-pathway inhibitor) (S)
Rabbit bladder urothelial cells
Yes
24 Wang DJ
2015 Rabbit 24
M Inlay (5)
Polylactid acid (S)
Rabbit AdSCs
Yes
25 Kelami A
1971 Dog 10
M Inlay (30)
PTFE (S) + lyophilized dura,
human (D)
—
Yes
26 Chung YG 2014 Rabbit 8
M Inlay (20)
Silk fibroin (N) + SIS (D)
—
Yes
27 Lv X
2016 Rabbit 18
M Inlay (15)
Silk-Keratin-Gelatin-Calcium
peroxide (N) + SIS, porcine (D)
—
Yes
28 Nuininga JE 2003 Rabbit 18
M Inlay (10)
SIS, 1 - and 4 - layer,
porcine (D) + Type I
collagen (N)
—
Yes
29 Zhang Q
2008 Rabbit 12
M Full (10)
Acellular amnion, human (D) Homologous endothelial
progenitor cells
Yes
30 Parnigotto PP 2000 Rabbit 12
M Full (10)
Acellular aorta, rabbit (D)
—
Yes
31 DeFilippo RE 2002 Rabbit 24
M Full (10)
BAM (D)
Autologous bladder SMCs and
urothelial cells
Yes
32 El-Tabey N 2012 Dog 14
F
Full (30)
BAM (D)
Autologous bladder SMCs and
urothelial cells
Yes
33 Wang JH 2013 Rabbit 18
M Full (30)
BAM with polylactid
acid –glycolic
acid with VEGF (D)
—
Yes
34 DeFilippo RE 2015 Rabbit 15
M Full (30)
BAM, porcine (D)
Autologous bladder SMCs and
urothelial cells
Yes
35 Dorin RP
2008 Rabbit 12
M Full (5–30)
BAM, porcine (D)
—
Yes
36 Orabi H
2012 Dog 21
M Full (60)
BAM, porcine (D)
Autologous bladder SMSs and
urothelial cells
Yes
E U R O P E A N U R O L O G Y 7 2 ( 2 0 1 7 ) 5 9 4 – 6 0 6
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