610
Ureteroscopy-assisted Percutaneous Kidney Access Made Easy: First Clinical Experience with a Novel Navigation System Using Electromagnetic Guidance (IDEAL Stage 1)E. Lima, P.L. Rodrigues, P. Mota, N. Carvalho, E. Dias, J. Correia-Pinto, R. Autorino, J.L. Vilaça
We describe the first clinical application of a novel navigation system using real-time
electromagnetic sensors to guide percutaneous kidney access. This new technology
allows safe, precise, fast, and effective ionizing radiation–free puncture of the renal
collecting system, and can facilitate one of the most challenging steps in
percutaneous removal of kidney stones.
617
Vessel-sparing Radiotherapy for Localized Prostate Cancer to Preserve Erectile Function: A Single-arm Phase 2 TrialD.E. Spratt, J.Y. Lee, R.T. Dess, V. Narayana, C. Evans, A. Liss, R. Winfield, M.J. Schipper,
T.S. Lawrence, P.W. McLaughlin
Vessel-sparing radiotherapy for men with localized prostate cancer using a novel
magnetic resonance imaging–based approach to spare erectile vasculature resulted
in 88%maintenance of sexual activity at 5 yr after treatment, 87% retention of
erections suitable for intercourse at 2 yr after treatment, and maintenance of tumor
control.
625
The Microbiome of the Prostate Tumor MicroenvironmentI. Cavarretta, R. Ferrarese, W. Cazzaniga, D. Saita, R. Lucianò, E.R. Ceresola, I. Locatelli, L. Visconti,
G. Lavorgna, A. Briganti, M. Nebuloni, C. Doglioni, M. Clementi, F. Montorsi, F. Canducci, A. Salonia
The prostate contains a plethora of bacteria, which set themselves within the gland
with a distribution dependent on the nature of the tissue, suggesting a possible
pathophysiological correlation between the specific local microbial niche and the
tumor itself.
632
Development and Internal Validation of a Novel Model to Identify the Candidates for Extended Pelvic Lymph Node Dissection in Prostate CancerG. Gandaglia, N. Fossati, E. Zaffuto, M. Bandini, P. Dell’Oglio, C.A. Bravi, G. Fallara, F. Pellegrino,
L. Nocera, P.I. Karakiewicz, Z. Tian, M. Freschi, R. Montironi, F. Montorsi, A. Briganti
Our study reports an accurate model predicting lymph node invasion in patients
with localized prostate cancer. The implementation of this model in clinical practice
would reduce the number of unnecessary lymph node dissections.
641
Comprehensive Genomic Characterization of Upper Tract Urothelial CarcinomaT.J. Moss, Y. Qi, L. Xi, B. Peng, T.-B. Kim, N.E. Ezzedine, M.E. Mosqueda, C.C. Guo, B.A. Czerniak,
M. Ittmann, D.A. Wheeler, S.P. Lerner, S.F. Matin
We performed an integrated, comprehensive genomic characterization of upper
tract urothelial carcinoma, evaluating DNA, RNA, and protein expression. We
identified a novel fusion mutation that regulates RTK signaling, and characterized
four molecular subtypes that appear to have distinct clinical behaviors.
650
Re: Inhibition of Cholinergic Neurotransmission by 3 -adrenoceptors Depends on Adenosine Release and A 1 Receptors Activation in Human and Rat Urinary BladdersK.-E. Andersson
651
Re: Women with Symptoms of a Urinary Tract Infection but a Negative Urine Culture: PCR-based Quantification of Escherichia coli Suggests Infection in Most CasesT.E. Bjerklund Johansen, T. Cai
652
Re: Treatment Duration of Febrile Urinary Tract Infection: A Pragmatic Randomized, Double-blind, Placebo-controlled Non-inferiority Trial in Men and WomenM.J. Grabe
e u r o p e a n u r o l o g y , vo l . 7 2 , n o . 4 , Oc t o b e r 2 0 1 7
Words ofWisdom
Surgery in Motion
Original Articles
Prostate Cancer
Urothelial Cancer




