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610

Ureteroscopy-assisted Percutaneous Kidney Access Made Easy: First Clinical Experience with a Novel Navigation System Using Electromagnetic Guidance (IDEAL Stage 1)

E. Lima, P.L. Rodrigues, P. Mota, N. Carvalho, E. Dias, J. Correia-Pinto, R. Autorino, J.L. Vilaça

We describe the first clinical application of a novel navigation system using real-time

electromagnetic sensors to guide percutaneous kidney access. This new technology

allows safe, precise, fast, and effective ionizing radiation–free puncture of the renal

collecting system, and can facilitate one of the most challenging steps in

percutaneous removal of kidney stones.

617

Vessel-sparing Radiotherapy for Localized Prostate Cancer to Preserve Erectile Function: A Single-arm Phase 2 Trial

D.E. Spratt, J.Y. Lee, R.T. Dess, V. Narayana, C. Evans, A. Liss, R. Winfield, M.J. Schipper,

T.S. Lawrence, P.W. McLaughlin

Vessel-sparing radiotherapy for men with localized prostate cancer using a novel

magnetic resonance imaging–based approach to spare erectile vasculature resulted

in 88%maintenance of sexual activity at 5 yr after treatment, 87% retention of

erections suitable for intercourse at 2 yr after treatment, and maintenance of tumor

control.

625

The Microbiome of the Prostate Tumor Microenvironment

I. Cavarretta, R. Ferrarese, W. Cazzaniga, D. Saita, R. Lucianò, E.R. Ceresola, I. Locatelli, L. Visconti,

G. Lavorgna, A. Briganti, M. Nebuloni, C. Doglioni, M. Clementi, F. Montorsi, F. Canducci, A. Salonia

The prostate contains a plethora of bacteria, which set themselves within the gland

with a distribution dependent on the nature of the tissue, suggesting a possible

pathophysiological correlation between the specific local microbial niche and the

tumor itself.

632

Development and Internal Validation of a Novel Model to Identify the Candidates for Extended Pelvic Lymph Node Dissection in Prostate Cancer

G. Gandaglia, N. Fossati, E. Zaffuto, M. Bandini, P. Dell’Oglio, C.A. Bravi, G. Fallara, F. Pellegrino,

L. Nocera, P.I. Karakiewicz, Z. Tian, M. Freschi, R. Montironi, F. Montorsi, A. Briganti

Our study reports an accurate model predicting lymph node invasion in patients

with localized prostate cancer. The implementation of this model in clinical practice

would reduce the number of unnecessary lymph node dissections.

641

Comprehensive Genomic Characterization of Upper Tract Urothelial Carcinoma

T.J. Moss, Y. Qi, L. Xi, B. Peng, T.-B. Kim, N.E. Ezzedine, M.E. Mosqueda, C.C. Guo, B.A. Czerniak,

M. Ittmann, D.A. Wheeler, S.P. Lerner, S.F. Matin

We performed an integrated, comprehensive genomic characterization of upper

tract urothelial carcinoma, evaluating DNA, RNA, and protein expression. We

identified a novel fusion mutation that regulates RTK signaling, and characterized

four molecular subtypes that appear to have distinct clinical behaviors.

650

Re: Inhibition of Cholinergic Neurotransmission by 3 -adrenoceptors Depends on Adenosine Release and A 1 Receptors Activation in Human and Rat Urinary Bladders

K.-E. Andersson

651

Re: Women with Symptoms of a Urinary Tract Infection but a Negative Urine Culture: PCR-based Quantification of Escherichia coli Suggests Infection in Most Cases

T.E. Bjerklund Johansen, T. Cai

652

Re: Treatment Duration of Febrile Urinary Tract Infection: A Pragmatic Randomized, Double-blind, Placebo-controlled Non-inferiority Trial in Men and Women

M.J. Grabe

e u r o p e a n u r o l o g y , vo l . 7 2 , n o . 4 , Oc t o b e r 2 0 1 7

Words ofWisdom

Surgery in Motion

Original Articles

Prostate Cancer

Urothelial Cancer