621 656
[(Fig._2)TD$FIG]
Fig. 2 – Erectile function preservation rates comparing radiotherapy with and without the use of androgen deprivation therapy. Physician-reported
metrics: (A) erectile function preservation and (B) sexually active (*
p
= 0.006 at 2 yr,
p
< 0.001 at 5 yr). Patient-reported metrics: (C) free from using
sexual aids (*
p
= 0.001 at 2 yr), (D) maintenance of IIEF-5 score
I
16, (E) having moderate to very high confidence of achieving and keeping an
erection (IEFF question #1), and (F) ability to be sexually active with or without the use of aids (three-question inventory). IIEF = International Index of
Erectile Function.
Table 4 – Comparison of functional erection rates for vessel-sparing radiotherapy with other trials and prospective cohorts
Study and cohort
Patients
Period
Age GS 6 (%)
BP men
Sexual aid use (%)
(
n
)
(yr)
retaining FE 2 yr after treatment (%)
aBaseline 2 yr
Prostatectomy
PCOS
[6]1164
1994–1995 64 64 (GS 2–4)
43
bNR
NR
PIVOT
[5]364
1994–2002 67 72
34
cNR
NR
CaPSURE
[18]1308
1995–2007 62 NR
33
NR
NR
ProtecT
[24]553
1999–2009 62 76
29
NR
NR
PROSTQA
[18]510
2003–2006 60 61
42
26
66
Conventional EBRT
PCOS
[6]491
1994–1995 69 59 (GS 2–4)
68
bNR
NR
CaPSURE
[18]247
1995–2007 72 NR
45
NR
NR
ProtecT
[24]545
1999–2009 62 78
50
NR
NR
PROSTQA
[18]228
2003–2006 70 44
69
23
32
Vessel-sparing radiotherapy
Present study
135
2001–2009 63 44
87
12
53
BP = baseline potent; FE = functional erections; GS = Gleason score; EBRT = external beam radiotherapy; EPIC = Expanded Prostate Cancer Index Composite;
NR = not reported; PCOS = Prostate Cancer Outcomes Study (‘‘Have you had any erections firm [hard] enough for sexual intercourse?’’, yes/no); PIVOT = Prostate
Cancer Intervention versus Observation Trial (‘‘sufficient for vaginal penetration’’, yes/no); CaPSURE = Cancer of the Prostate Strategic Urologic Research
Endeavor; utilized UCLA-PCI. ProtecT = Prostate Testing for Cancer and Treatment (EPIC-based assessment); PROSTQA = Prostate Cancer Outcomes and
Satisfaction with Treatment Quality Assessment (EPIC-based assessment).
a
The 2-yr percentage FE reported divided by the percentage baseline FE.
b
Did not collect baseline FE rates and were extrapolated after the 6-mo post-treatment time point.
c
Did not report baseline FE rates. Calculations were based on dividing the 2-yr rates for the surgical arm by the 2-yr rates for the observation arm.
E U R O P E A N U R O L O G Y 7 2 ( 2 0 1 7 ) 6 1 7 – 6 2 4
621