636 656
Table 2 – Uni- and multivariable logistic regression analyses assessing predicting the presence of lymph node invasion in 681 patients treated with radical prostatectomy and extended pelvic
lymph node dissection
Model 1
Model 2
Model 3
Model 4
Univariable analyses
Multivariable analyses
Multivariable analyses
Multivariable analyses
Multivariable analyses
OR (95% CI)
p
value
OR (95% CI)
p
value
OR (95% CI)
p
value
OR (95% CI)
p
value
OR (95% CI)
p
value
Preoperative PSA
1.11 (1.09–1.15)
<
0.001 1.08 (1.05–1.12)
<
0.001 1.08 (1.05–1.12)
<
0.001 1.09 (1.06–1.12)
<
0.001 1.08 (1.05–1.11)
<
0.001
Clinical stage
T1
1 (Ref.)
1 (Ref.)
1 (Ref.)
1 (Ref.)
1 (Ref.)
T2
3.75 (2.11–6.68)
<
0.001 2.27 (1.06–4.87)
0.03 2.27 (1.05–4.76)
0.03 2.01 (1.02–4.17)
0.04 2.06 (1.01–4.25)
0.049
T3
16.4 (7.6–35.4)
<
0.001 2.87 (1.03–8.12)
0.04 2.76 (1.03–7.87)
0.045 2.57 (1.00–7.16)
0.05 2.65 (0.94–7.37)
0.06
Biopsy Gleason grade group
1–2
1 (Ref.)
1 (Ref.)
1 (Ref.)
1 (Ref.)
1 (Ref.)
3
15.5 (7.7–29.9)
<
0.001 9.5 (4.4–21.1)
<
0.001 9.5 (4.3–20.8)
<
0.001 8.3 (3.8–18.2)
<
0.001 9.03 (4.1–19.9)
<
0.001
4–5
28.9 (14.5–47.6)
<
0.001 14.5 (6.6–29.9)
<
0.001 13.9 (6.2–31.5)
<
0.001 10.6 (4.8–23.5)
<
0.001 13.3 (5.8–29.8)
<
0.001
Percentage of positive cores
1.03 (1.02-1.04)
<
0.001 –
–
–
–
–
–
–
–
Percentage of positive cores with highest-grade PCa 1.03 (1.02–1.04)
<
0.001 1.02 (1.01–1.04)
<
0.001 1.02 (1.01–1.04)
<
0.001 1.03 (1.01–1.05)
0.001 1.02 (1.01–1.03)
0.01
Percentage of positive cores with lower-grade PCa
1.03 (1.01–1.04)
<
0.001 1.01 (0.99–1.03)
0.2
1.01 (0.98–1.03)
0.3
0.98 (0.95–1.02)
0.4
1.01 (0.99–1.04)
0.2
Maximum percentage of single core
involvement with highest-grade PCa
1.04 (1.03–1.04)
<
0.001 –
–
–
–
1.00 (0.98–1.01)
0.8
–
–
Maximum percentage of single core
involvement with lower-grade PCa
1.02 (1.01–1.03)
<
0.001 –
–
–
–
1.01 (0.99–1.03)
0.1
–
–
Percentage of tumor in biopsy cores
1.05 (1.04–1.06)
<
0.001 –
–
1.01 (0.99–1-04)
0.3
–
–
–
–
Percentage of highest-grade PCa in biopsy cores
1.05 (1.04–1.07)
<
0.001 –
–
–
–
–
–
1.01 (0.98–1.04)
0.4
Percentage of lower-grade PCa in biopsy cores
1.02 (1.00–1.05)
0.04 –
–
–
–
–
–
0.99 (0.97–1.02)
0.8
AUC of multivariable models (%)
–
–
91
–
91
–
91
–
91
–
AUC = area under the curve; OR = odds ratio; CI = confidence interval; PCa = prostate cancer; Ref. = reference.
E U R O P E A N U R O L O G Y 7 2 ( 2 0 1 7 ) 6 3 2 – 6 4 0
636